Thyroid
Thyroid health and healing talk April 25th
23/04/12 14:57
by Kate Whimster, BCom, MIFHI, ND
I will be giving a free talk called Thyroid Health and Healing on Wednesday, April 25th, 7pm at the Main Street Library (137 Main Street, Toronto). Call the library at 416-393-7700 to RSVP!
The “master gland” of the body, your thyroid influences both body and mind. Learn how to understand thyroid testing and treatment options to support thyroid health.
See my Appearances and Events page for more upcoming dates and topics!
I will be giving a free talk called Thyroid Health and Healing on Wednesday, April 25th, 7pm at the Main Street Library (137 Main Street, Toronto). Call the library at 416-393-7700 to RSVP!
The “master gland” of the body, your thyroid influences both body and mind. Learn how to understand thyroid testing and treatment options to support thyroid health.
See my Appearances and Events page for more upcoming dates and topics!
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Thyroid health and healing talk April 18th
12/04/12 09:13
by Kate Whimster, BCom, MIFHI, ND
I will be giving a free talk called Thyroid Health and Healing on Wednesday, April 18th, 7pm at the Deer Park Library (40 St. Clair Avenue East, Toronto). Call the library at 416-393-7657 to RSVP!
The “master gland” of the body, your thyroid influences both body and mind. Learn how to understand thyroid testing and treatment options to support thyroid health.
See my Appearances and Events page for more upcoming dates and topics!
I will be giving a free talk called Thyroid Health and Healing on Wednesday, April 18th, 7pm at the Deer Park Library (40 St. Clair Avenue East, Toronto). Call the library at 416-393-7657 to RSVP!
The “master gland” of the body, your thyroid influences both body and mind. Learn how to understand thyroid testing and treatment options to support thyroid health.
See my Appearances and Events page for more upcoming dates and topics!
Guest post: The scoop on fish oils
25/11/11 17:27
Guest post originally published by Negin Misaghi, ND
I’m not much into miracles especially where medicine is concerned. Fish oils however, are without question today’s miracle medicine! I should clarify however that fish oil is a miracle in the sense that it’s a very potent healer, and not a miracle as far as the definition of this word is concerned - with regards to it being supernatural or incomprehensible. Far from it! In fact, the mechanism of action of fish oils with regards to its therapeutic effects are very well understood.
Everything in our lifestyle from our standard diet to our hectic stress-filled day-to-day living, to our sedentary city life of drive-through’s and desk jobs, and machines of all functionalities has made us ‘inflammatory’ – in every sense of the word!
With our diet of highly refined grains and sugars, high consumption of inflammatory vegetable oils (omega 6’s) and animal products (meats & dairy) as a staple, our bodies have become pathologically inflammatory. Our sedentary lifestyle on the other hand only adds to the ordeal since exercise lowers inflammation. The stress hormone cortisol is then released as a result of inflammation as an attempt to bring some balance due to cortisol’s anti-inflammatory properties. This however only adds to the disorder as over time the elevated levels of cortisol not only add to your perceived stress but also result in a number of disease processes. Remember that cortisol is released as our fight or flight stress response resulting in changes in the cardiovascular system (increased blood pressure), causing release of sugars in the body (contributing to diabetes), disrupting thyroid hormone functioning, depressing the immune system, and, and, and… contributing to an endless list of syndromes!
From a Traditional Chinese Medicine perspective, our inflammatory and stress-filled lifestyle causes damage to the liver. Once the liver has reached its capacity, damages begin to affect the heart and kidneys also. Chinese Medicine among many traditional medical beliefs (like Ayurveda and others) links each organ system to an emotion. The liver when pathological causes feelings of anger - hence, inflammation in every sense of the word! When damages reach the heart, depression and anxiety set in, and once the kidneys begin to take the grunt of the insult and are damaged, fears and insecurities begin to surface (just to show how entwined our body systems are where an imbalance of one system puts pressure on others and if chronic, can upset the harmony of the whole body).
This is where fish oils can have a great impact on the health of an individual both physically as well as mentally and emotionally. Fish oils have demonstrated strong anti-inflammatory properties for conditions that are inflammatory in nature (arthritis, heart disease, metabolic syndrome and insulin insensitivity (diabetes)). As well, fish oils have been found to be effective for the treatment of depression (recent research has linked depression to chronic inflammation).
Although fish oils benefit almost every health condition of today as most result from chronic inflammation, it should also be noted that if there’s still gas feeding the fire of inflammation (i.e. the root cause of inflammation has not been removed), fish oils would only be a band-aid solution. To learn more about how inflammation can be controlled at its root, seek the advice of a licensed naturopathic doctor. In the meantime, consider supplementation with fish oils to keep inflammation in check!
I should also mention that the EPA component of fish oil is responsible for its anti-inflammatory properties and NO vegetarian source of Omega 3’s contains EPA.
To be discussed in a later post: Why animal sources of omega 3′s are superior to vegetarian sources, why dietary sources of fish oils are not sufficient for some, and best(safe) fish to consume for their omega 3 content!
Thyroid, iodine, and breast health
03/07/09 10:53
by Kate Whimster, BCom, MIFHI, ND
This blog was originally published on December 2, 2008 here.
I wrote a research paper looking the relationships between thyroid function, breast pathologies, and the role of iodine supplementation. This blog is a summary of what I learned. References are listed at the end and can be found on PubMed.
First, thyroid. There is an observed correlation between thyroid dysfunction and breast cancer (1,2,3), particularly hypothyroidism (3,4). Decreased function of the thyroid gland and rising TSH are also associated with a doubling in the risk of development of fibrocystic breast disease (5).
Next, iodine and breasts. Both breast tissue and thyroid tissue concentrate iodine (6) and deficiency of iodine causes “atypical tissue and physiologic changes in both” (7). One researcher noted that “geographic differences in the rates of breast, endometrial, and ovarian cancer appear to be inversely correlated with dietary iodine intake” (8). For example, in Japan seaweed (high in both iodine and selenium) is a major part of the diet and may play a role in the low incidence of both benign and malignant breast disease in that country (9).
A study on rats demonstrated a reduction in breast cancer incidence with iodine treatment (10). With regard to fibrocystic breast disease, randomized, double-blind, placebo-controlled, multicenter clinical trials (the gold-standard of conventional medicine!) have demonstrated that supplementation with iodide/iodine significantly reduced breast pain, tenderness, and nodularity (11,12).
So how does this work? One theory is that iodine deficiency leads to a state of excess estrogen (13), increasing the risk of a whole host of cancers. Iodine is also believed to suppress tumour growth (14), induce tumour cell death (15), and regulate genes that influence hormone metabolism, cell cycle, growth, and differentiation (16).
Why is this useful information? Everything in the body is connected, particularly the endocrine system. So, when something is going wrong in one area, like thyroid function, there are likely also going to be issues either immediately or down the road with another area, particularly reproductive organs. The causal mechanisms are not clear yet, but it is prudent to assess breast health when patients present with thyroid dysfunction and vice versa. There is evidence to suggest that iodine is effective nutritional treatment for fibrocystic breast disease and it may also be useful in reproductive cancers. Molecular iodine, rather than iodide, was found to be most effective and have the least adverse effects on the thyroid (12).
There is lots of other interesting information that I was not able to get to, such as a deeper look at the interaction of sex hormones with thyroid function and other influences on hormonal balance, such as sleep. Maybe one day I’ll have time to do more research and I’ll post an update!
References:
1. Turken O, NarIn Y, DemIrbas S, Onde ME, Sayan O, KandemIr EG, YaylacI M, Ozturk A. Breast cancer in association with thyroid disorders. Breast Cancer Res. 2003;5(5):R110-3. Epub 2003 Jun 5. PMID: 12927040
2. Saraiva PP, Figueiredo NB, Padovani CR, Brentani MM, Nogueira CR. Profile of thyroid hormones in breast cancer patients. Braz J Med Biol Res. 2005 May;38(5):761-5. Epub 2005 May 25. PMID: 15917958
3. Giani C, Fierabracci P, Bonacci R, Gigliotti A, Campani D, De Negri F, Cecchetti D, Martino E, Pinchera A. Relationship between breast cancer and thyroid disease: relevance of autoimmune thyroid disorders in breast malignancy. J Clin Endocrinol Metab. 1996 Mar;81(3):990-4.
4. Kuijpens JL, Nyklíctek I, Louwman MW, Weetman TA, Pop VJ, Coebergh JW. Hypothyroidism might be related to breast cancer in post-menopausal women. Thyroid. 2005 Nov;15(11):1253-9. PMID: 16356089
5. Mardaleishvili KG, Nemsadze GG, Metreveli DS, Roinishvili TL. [About correlation of dysfunction of the thyroid gland with fibrocystic diseases in women] Georgian Med News. 2006 Nov;(140):30-2. Russian.
6. Patrick L. Iodine: deficiency and therapeutic considerations. Altern Med Rev. 2008 Jun;13(2):116-27. Review. PMID: 18590348
7. Eskin BA, Grotkowski CE, Connolly CP, Ghent WR. Different tissue responses for iodine and iodide in rat thyroid and mammary glands. Biol Trace Elem Res. 1995 Jul;49(1):9-19. PMID: 7577324
8. Stadel BV. Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet. 1976 Apr 24;1(7965):890-1. PMID: 58152
9. Cann SA, van Netten JP, van Netten C. Hypothesis: iodine, selenium and the development of breast cancer. Cancer Causes Control. 2000 Feb;11(2):121-7. Review. PMID: 10710195
10. García-Solís P, Alfaro Y, Anguiano B, Delgado G, Guzman RC, Nandi S, Díaz-Muñoz M, Vázquez-Martínez O, Aceves C. Inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion. Mol Cell Endocrinol. 2005 May 31;236(1-2):49-57. Epub 2005 Apr 13. PMID: 15922087
11. Kessler JH. The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia. Breast J. 2004 Jul-Aug;10(4):328-36. PMID: 15239792
12. Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg. 1993 Oct;36(5):453-60. PMID: 8221402
13. Stadel BV. Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet. 1976 Apr 24;1(7965):890-1. PMID: 58152
14. Funahashi H, Imai T, Tanaka Y, Tobinaga J, Wada M, Morita T, Yamada F, Tsukamura K, Oiwa M, Kikumori T, Narita T, Takagi H. Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat. J Surg Oncol. 1996 Mar;61(3):209-13. PMID: 8637209
15. Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem. 2006 Jul 14;281(28):19762-71. Epub 2006 May 5. PMID: 16679319
16. Stoddard FR 2nd, Brooks AD, Eskin BA, Johannes GJ. Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine. Int J Med Sci. 2008 Jul 8;5(4):189-96. PMID: 18645607
This blog was originally published on December 2, 2008 here.
I wrote a research paper looking the relationships between thyroid function, breast pathologies, and the role of iodine supplementation. This blog is a summary of what I learned. References are listed at the end and can be found on PubMed.
First, thyroid. There is an observed correlation between thyroid dysfunction and breast cancer (1,2,3), particularly hypothyroidism (3,4). Decreased function of the thyroid gland and rising TSH are also associated with a doubling in the risk of development of fibrocystic breast disease (5).
Next, iodine and breasts. Both breast tissue and thyroid tissue concentrate iodine (6) and deficiency of iodine causes “atypical tissue and physiologic changes in both” (7). One researcher noted that “geographic differences in the rates of breast, endometrial, and ovarian cancer appear to be inversely correlated with dietary iodine intake” (8). For example, in Japan seaweed (high in both iodine and selenium) is a major part of the diet and may play a role in the low incidence of both benign and malignant breast disease in that country (9).
A study on rats demonstrated a reduction in breast cancer incidence with iodine treatment (10). With regard to fibrocystic breast disease, randomized, double-blind, placebo-controlled, multicenter clinical trials (the gold-standard of conventional medicine!) have demonstrated that supplementation with iodide/iodine significantly reduced breast pain, tenderness, and nodularity (11,12).
So how does this work? One theory is that iodine deficiency leads to a state of excess estrogen (13), increasing the risk of a whole host of cancers. Iodine is also believed to suppress tumour growth (14), induce tumour cell death (15), and regulate genes that influence hormone metabolism, cell cycle, growth, and differentiation (16).
Why is this useful information? Everything in the body is connected, particularly the endocrine system. So, when something is going wrong in one area, like thyroid function, there are likely also going to be issues either immediately or down the road with another area, particularly reproductive organs. The causal mechanisms are not clear yet, but it is prudent to assess breast health when patients present with thyroid dysfunction and vice versa. There is evidence to suggest that iodine is effective nutritional treatment for fibrocystic breast disease and it may also be useful in reproductive cancers. Molecular iodine, rather than iodide, was found to be most effective and have the least adverse effects on the thyroid (12).
There is lots of other interesting information that I was not able to get to, such as a deeper look at the interaction of sex hormones with thyroid function and other influences on hormonal balance, such as sleep. Maybe one day I’ll have time to do more research and I’ll post an update!
References:
1. Turken O, NarIn Y, DemIrbas S, Onde ME, Sayan O, KandemIr EG, YaylacI M, Ozturk A. Breast cancer in association with thyroid disorders. Breast Cancer Res. 2003;5(5):R110-3. Epub 2003 Jun 5. PMID: 12927040
2. Saraiva PP, Figueiredo NB, Padovani CR, Brentani MM, Nogueira CR. Profile of thyroid hormones in breast cancer patients. Braz J Med Biol Res. 2005 May;38(5):761-5. Epub 2005 May 25. PMID: 15917958
3. Giani C, Fierabracci P, Bonacci R, Gigliotti A, Campani D, De Negri F, Cecchetti D, Martino E, Pinchera A. Relationship between breast cancer and thyroid disease: relevance of autoimmune thyroid disorders in breast malignancy. J Clin Endocrinol Metab. 1996 Mar;81(3):990-4.
4. Kuijpens JL, Nyklíctek I, Louwman MW, Weetman TA, Pop VJ, Coebergh JW. Hypothyroidism might be related to breast cancer in post-menopausal women. Thyroid. 2005 Nov;15(11):1253-9. PMID: 16356089
5. Mardaleishvili KG, Nemsadze GG, Metreveli DS, Roinishvili TL. [About correlation of dysfunction of the thyroid gland with fibrocystic diseases in women] Georgian Med News. 2006 Nov;(140):30-2. Russian.
6. Patrick L. Iodine: deficiency and therapeutic considerations. Altern Med Rev. 2008 Jun;13(2):116-27. Review. PMID: 18590348
7. Eskin BA, Grotkowski CE, Connolly CP, Ghent WR. Different tissue responses for iodine and iodide in rat thyroid and mammary glands. Biol Trace Elem Res. 1995 Jul;49(1):9-19. PMID: 7577324
8. Stadel BV. Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet. 1976 Apr 24;1(7965):890-1. PMID: 58152
9. Cann SA, van Netten JP, van Netten C. Hypothesis: iodine, selenium and the development of breast cancer. Cancer Causes Control. 2000 Feb;11(2):121-7. Review. PMID: 10710195
10. García-Solís P, Alfaro Y, Anguiano B, Delgado G, Guzman RC, Nandi S, Díaz-Muñoz M, Vázquez-Martínez O, Aceves C. Inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion. Mol Cell Endocrinol. 2005 May 31;236(1-2):49-57. Epub 2005 Apr 13. PMID: 15922087
11. Kessler JH. The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia. Breast J. 2004 Jul-Aug;10(4):328-36. PMID: 15239792
12. Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg. 1993 Oct;36(5):453-60. PMID: 8221402
13. Stadel BV. Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet. 1976 Apr 24;1(7965):890-1. PMID: 58152
14. Funahashi H, Imai T, Tanaka Y, Tobinaga J, Wada M, Morita T, Yamada F, Tsukamura K, Oiwa M, Kikumori T, Narita T, Takagi H. Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat. J Surg Oncol. 1996 Mar;61(3):209-13. PMID: 8637209
15. Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem. 2006 Jul 14;281(28):19762-71. Epub 2006 May 5. PMID: 16679319
16. Stoddard FR 2nd, Brooks AD, Eskin BA, Johannes GJ. Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine. Int J Med Sci. 2008 Jul 8;5(4):189-96. PMID: 18645607
